Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response

Human immunodeficiency virus-1 subtypes A and C differ in the highly conserved Gag-TL9 epitope at a single amino acid position. Similarly, the TL9 presenting human leukocyte antigen (HLA) class I molecules B42 and B81 differ only at 6 amino acid positions. Here, we addressed the influence of such mi...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Geldmacher, Christof, Metzler, Ian S., Tovanabutra, Sodsai, Asher, Tedi E., Gostick, Emma, Ambrozak, David R., Petrovas, Constantinos, Schuetz, Alexandra, Ngwenyama, Njabulo, Kijak, Gustavo, Maboko, Leonard, Hoelscher, Michael, McCutchan, Francine, Price, David A., Douek, Daniel C., Koup, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731637/
https://ncbi.nlm.nih.gov/pubmed/19542300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206193
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky