Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response

Human immunodeficiency virus-1 subtypes A and C differ in the highly conserved Gag-TL9 epitope at a single amino acid position. Similarly, the TL9 presenting human leukocyte antigen (HLA) class I molecules B42 and B81 differ only at 6 amino acid positions. Here, we addressed the influence of such mi...

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Autors principals: Geldmacher, Christof, Metzler, Ian S., Tovanabutra, Sodsai, Asher, Tedi E., Gostick, Emma, Ambrozak, David R., Petrovas, Constantinos, Schuetz, Alexandra, Ngwenyama, Njabulo, Kijak, Gustavo, Maboko, Leonard, Hoelscher, Michael, McCutchan, Francine, Price, David A., Douek, Daniel C., Koup, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731637/
https://ncbi.nlm.nih.gov/pubmed/19542300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206193
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