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Differential Recruitment of Nuclear Coregulators Directs the Isoform-Dependent Action of Mutant Thyroid Hormone Receptors

Studies using mice deficient in thyroid hormone receptors (TR) indicate that the two TR isoforms, TRα1 and TRβ1, in addition to mediating overlapping biological activities of the thyroid hormone, T3, also mediate distinct functions. Mice harboring an identical dominant negative mutation (denoted PV)...

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書誌詳細
主要な著者: Fozzatti, Laura, Lu, Changxue, Kim, Dong-Wook, Cheng, Sheue-yann
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100599/
https://ncbi.nlm.nih.gov/pubmed/21474540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0474
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