Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms

To understand the roles of thyroid hormone receptors (TRs) in adipogenesis, we adopted a loss-of-function approach. We generated 3T3-L1 cells stably expressing either TRα1 mutant (TRα1PV) or TRβ1 mutant (TRβ1PV). TRα1PV and TRβ1PV are dominant negative mutations with a frameshift in the C-terminal a...

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Bibliografiske detaljer
Main Authors: Mishra, Alok, Zhu, Xu-guang, Ge, Kai, Cheng, Sheue-Yann
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464097/
https://ncbi.nlm.nih.gov/pubmed/20080985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JME-09-0137
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