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Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms
To understand the roles of thyroid hormone receptors (TRs) in adipogenesis, we adopted a loss-of-function approach. We generated 3T3-L1 cells stably expressing either TRα1 mutant (TRα1PV) or TRβ1 mutant (TRβ1PV). TRα1PV and TRβ1PV are dominant negative mutations with a frameshift in the C-terminal a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464097/ https://ncbi.nlm.nih.gov/pubmed/20080985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JME-09-0137 |
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