Differential Recruitment of Nuclear Coregulators Directs the Isoform-Dependent Action of Mutant Thyroid Hormone Receptors

Studies using mice deficient in thyroid hormone receptors (TR) indicate that the two TR isoforms, TRα1 and TRβ1, in addition to mediating overlapping biological activities of the thyroid hormone, T3, also mediate distinct functions. Mice harboring an identical dominant negative mutation (denoted PV)...

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Detaylı Bibliyografya
Asıl Yazarlar: Fozzatti, Laura, Lu, Changxue, Kim, Dong-Wook, Cheng, Sheue-yann
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2011
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100599/
https://ncbi.nlm.nih.gov/pubmed/21474540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0474
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