Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α

Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms by which TRα1 mutants exert dominant negative activity in vivo are not cle...

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Bibliographic Details
Main Authors: Fozzatti, Laura, Kim, Dong Wook, Park, Jeong Won, Willingham, Mark C., Hollenberg, Anthony N., Cheng, Sheue-Yann
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651436/
https://ncbi.nlm.nih.gov/pubmed/23610395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222334110
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