Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α

Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms by which TRα1 mutants exert dominant negative activity in vivo are not cle...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fozzatti, Laura, Kim, Dong Wook, Park, Jeong Won, Willingham, Mark C., Hollenberg, Anthony N., Cheng, Sheue-Yann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651436/
https://ncbi.nlm.nih.gov/pubmed/23610395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222334110
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