Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)

Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) lead to resistance to thyroid hormone (RTH). These TRβ mutants function in a dominant-negative fashion to interfere with the transcription activity of wild-type thyroid hormone receptors (TRs), leading to dysregulation of...

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Dettagli Bibliografici
Autori principali: Fozzatti, Laura, Lu, Changxue, Kim, Dong Wook, Park, Jeong Won, Astapova, Inna, Gavrilova, Oksana, Willingham, Mark C., Hollenberg, Anthony N., Cheng, Sheue-yann
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198316/
https://ncbi.nlm.nih.gov/pubmed/21987803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107474108
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