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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)
Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) lead to resistance to thyroid hormone (RTH). These TRβ mutants function in a dominant-negative fashion to interfere with the transcription activity of wild-type thyroid hormone receptors (TRs), leading to dysregulation of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198316/ https://ncbi.nlm.nih.gov/pubmed/21987803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107474108 |
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