N-(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl) piperazine-1-yl)-butyl)-aryl carboxamides as Selective Dopamine D3 Receptor Ligands: Critical Role of the Carboxamide Linker for D3 Receptor Selectivity

N-(3-fluoro-4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazine-1-yl)-butyl)-aryl carboxamides were prepared and evaluated for binding and function at dopamine D3 (D3R) and D2 receptors (D2R). In this series, we discovered some of the most D3R selective compounds reported to date, (e.g. 8d and 8j >...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Banala, Ashwini K., Levy, Benjamin A., Khatri, Sameer S., Furman, Cheryse A., Roof, Rebecca A., Mishra, Yogesh, Griffin, Suzy A., Sibley, David R., Luedtke, Robert R., Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100590/
https://ncbi.nlm.nih.gov/pubmed/21495689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200288r
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados