Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

The RASSF1A tumor suppressor binds and activates proapoptotic MST kinases. The Salvador adaptor protein couples MST kinases to the LATS kinases to form the hippo pathway. Upon activation by RASSF1A, LATS1 phosphorylates the transcriptional regulator YAP, which binds to p73 and activates its proapopt...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Donninger, Howard, Allen, Nadia, Henson, Adrianna, Pogue, Jennifer, Williams, Andrew, Gordon, Laura, Kassler, Susannah, Dunwell, Thomas, Latif, Farida, Clark, Geoffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099665/
https://ncbi.nlm.nih.gov/pubmed/21489991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214874
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker