Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

The RASSF1A tumor suppressor binds and activates proapoptotic MST kinases. The Salvador adaptor protein couples MST kinases to the LATS kinases to form the hippo pathway. Upon activation by RASSF1A, LATS1 phosphorylates the transcriptional regulator YAP, which binds to p73 and activates its proapopt...

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Bibliografske podrobnosti
Main Authors: Donninger, Howard, Allen, Nadia, Henson, Adrianna, Pogue, Jennifer, Williams, Andrew, Gordon, Laura, Kassler, Susannah, Dunwell, Thomas, Latif, Farida, Clark, Geoffrey J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099665/
https://ncbi.nlm.nih.gov/pubmed/21489991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214874
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