Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

The RASSF1A tumor suppressor binds and activates proapoptotic MST kinases. The Salvador adaptor protein couples MST kinases to the LATS kinases to form the hippo pathway. Upon activation by RASSF1A, LATS1 phosphorylates the transcriptional regulator YAP, which binds to p73 and activates its proapopt...

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Autores principales: Donninger, Howard, Allen, Nadia, Henson, Adrianna, Pogue, Jennifer, Williams, Andrew, Gordon, Laura, Kassler, Susannah, Dunwell, Thomas, Latif, Farida, Clark, Geoffrey J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099665/
https://ncbi.nlm.nih.gov/pubmed/21489991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214874
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