Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

The RASSF1A tumor suppressor binds and activates proapoptotic MST kinases. The Salvador adaptor protein couples MST kinases to the LATS kinases to form the hippo pathway. Upon activation by RASSF1A, LATS1 phosphorylates the transcriptional regulator YAP, which binds to p73 and activates its proapopt...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Donninger, Howard, Allen, Nadia, Henson, Adrianna, Pogue, Jennifer, Williams, Andrew, Gordon, Laura, Kassler, Susannah, Dunwell, Thomas, Latif, Farida, Clark, Geoffrey J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099665/
https://ncbi.nlm.nih.gov/pubmed/21489991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214874
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars