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Synthesis and properties of triazole-linked RNA

RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7 to 14 °C per modification). NMR data suggested that, despite relative flex...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mutisya, Daniel, Selvam, Chelliah, Kennedy, Scott D., Rozners, Eriks
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099469/
https://ncbi.nlm.nih.gov/pubmed/21524577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.111
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