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Synthesis and properties of triazole-linked RNA

RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7 to 14 °C per modification). NMR data suggested that, despite relative flex...

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Bibliografische gegevens
Hoofdauteurs: Mutisya, Daniel, Selvam, Chelliah, Kennedy, Scott D., Rozners, Eriks
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099469/
https://ncbi.nlm.nih.gov/pubmed/21524577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.111
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