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PNA containing isocytidine nucleobase: synthesis and recognition of double helical RNA

Peptide nucleic acid (PNA1) containing a 5-methylisocytidine (iC) nucleobase has been synthesized. Triple helix formation between PNA1 and RNA hairpins having variable base pairs interacting with iC was studied using isothermal titration calorimetry. The iC nucleobase recognized the proposed target,...

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Bibliografske podrobnosti
Main Authors: Zengeya, Thomas, Li, Ming, Rozners, Eriks
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056986/
https://ncbi.nlm.nih.gov/pubmed/21333533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.01.130
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