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Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates

Conjugation of short peptide nucleic acids (PNA) with tetralysine peptides strongly enhanced triple helical binding to RNA at physiologically relevant conditions. The PNA hexamers and heptamers carrying cationic nucleobase and tetralysine modifications displayed high binding affinity for complementa...

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Autors principals: Muse, Oluwatoyosi, Zengeya, Thomas, Mwaura, Juddy, Hnedzko, Dziyana, McGee, Dennis W., Grewer, Christof T., Rozners, Eriks
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745792/
https://ncbi.nlm.nih.gov/pubmed/23721369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400144x
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