Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates

Conjugation of short peptide nucleic acids (PNA) with tetralysine peptides strongly enhanced triple helical binding to RNA at physiologically relevant conditions. The PNA hexamers and heptamers carrying cationic nucleobase and tetralysine modifications displayed high binding affinity for complementa...

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Hauptverfasser: Muse, Oluwatoyosi, Zengeya, Thomas, Mwaura, Juddy, Hnedzko, Dziyana, McGee, Dennis W., Grewer, Christof T., Rozners, Eriks
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745792/
https://ncbi.nlm.nih.gov/pubmed/23721369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400144x
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