Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates

Conjugation of short peptide nucleic acids (PNA) with tetralysine peptides strongly enhanced triple helical binding to RNA at physiologically relevant conditions. The PNA hexamers and heptamers carrying cationic nucleobase and tetralysine modifications displayed high binding affinity for complementa...

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Bibliographic Details
Main Authors: Muse, Oluwatoyosi, Zengeya, Thomas, Mwaura, Juddy, Hnedzko, Dziyana, McGee, Dennis W., Grewer, Christof T., Rozners, Eriks
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745792/
https://ncbi.nlm.nih.gov/pubmed/23721369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400144x
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