Loading...

Synthesis and properties of triazole-linked RNA

RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7 to 14 °C per modification). NMR data suggested that, despite relative flex...

Full description

Saved in:
Bibliographic Details
Main Authors: Mutisya, Daniel, Selvam, Chelliah, Kennedy, Scott D., Rozners, Eriks
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099469/
https://ncbi.nlm.nih.gov/pubmed/21524577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.111
Tags: Add Tag
No Tags, Be the first to tag this record!