GTP Cyclohydrolase I: Purification, Characterization, and Effects of Inhibition on Nitric Oxide Synthase in Nocardia Species

GTP cyclohydrolase I (GTPCH) catalyzes the first step in pteridine biosynthesis in Nocardia sp. strain NRRL 5646. This enzyme is important in the biosynthesis of tetrahydrobiopterin (BH(4)), a reducing cofactor required for nitric oxide synthase (NOS) and other enzyme systems in this organism. GTPCH...

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Bibliographic Details
Main Authors: He, Aimin, Rosazza, John P. N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Enzymology and Protein Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC309945/
https://ncbi.nlm.nih.gov/pubmed/14660404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.12.7507-7513.2003
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