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GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP

Our previous studies have demonstrated that nitric oxide (NO) leads to nitric oxide synthase (NOS) uncoupling and an increase in NOS-derived superoxide. However, the cause of this uncoupling has not been adequately resolved. The pteridine cofactor tetrahydrobiopterin (BH(4)) is a critical determinan...

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Bibliografiske detaljer
Main Authors: Kumar, Sanjiv, Sun, Xutong, Sharma, Shruti, Aggarwal, Saurabh, Ravi, Kandasamy, Fineman, Jeffery R., Black, Stephen M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742798/
https://ncbi.nlm.nih.gov/pubmed/19447893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90538.2008
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