PRESERVING MITOCHONDRIAL FUNCTION PREVENTS THE PROTEASOMAL DEGRADATION OF GTP CYCLOHYDROLASE I

The development of pulmonary hypertension is a common accompaniment of congenital heart disease (CHD) with increased pulmonary blood flow. Our recent evidence suggests that asymmetric dimethylarginine (ADMA)-induced mitochondrial dysfunction causes endothelial nitric oxide synthase (eNOS) uncoupling...

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Main Authors: SHARMA, SHRUTI, SUN, XUTONG, KUMAR, SANJIV, RAFIKOV, RUSLAN, ARAMBURO, ANGELA, KALKAN, GOKHAN, TIAN, JING, REHMANI, IMRAN, KALLARACKAL, SUPHIN, FINEMAN, JEFFERY R., BLACK, STEPHEN M.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527085/
https://ncbi.nlm.nih.gov/pubmed/22583703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.03.016
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