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Acute Inhibition of GTP Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase (eNOS) dictating at least partly, the balance of nitric oxide (NO) and superoxide (O(2)(•−)) produced by this enzyme. The aim of th...

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Main Authors: Wang, Shuangxi, Xu, Jian, Song, Ping, Wu, Yong, Zhang, Junhua, Choi, Hyoung Chul, Zou, Ming-Hui
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523107/
https://ncbi.nlm.nih.gov/pubmed/18645049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.112094
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