Acute Inhibition of GTP Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase (eNOS) dictating at least partly, the balance of nitric oxide (NO) and superoxide (O(2)(•−)) produced by this enzyme. The aim of th...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Shuangxi, Xu, Jian, Song, Ping, Wu, Yong, Zhang, Junhua, Choi, Hyoung Chul, Zou, Ming-Hui
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523107/
https://ncbi.nlm.nih.gov/pubmed/18645049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.112094
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