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Activation of NAD(P)H oxidases by Thromboxane A(2) Receptor Uncouples Endothelial Nitric Oxide Synthase

OBJECTIVE: The thromboxane receptor (TPr) and multiple TPr ligands, including thromboxane A(2) (TxA(2)) and prostaglandin H(2) (PGH(2)), are elevated during vascular and atherothrombotic diseases. How TPr stimulation causes vascular injury remains poorly defined. This study was conducted to investig...

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Autori principali: Zhang, Miao, Song, Ping, Xu, Jian, Zou, Ming-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005129/
https://ncbi.nlm.nih.gov/pubmed/20947827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.207712
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