Mechanistic Studies of the Radical SAM Enzyme DesII: EPR Characterization of a Radical Intermediate Generated During Its Catalyzed Dehydrogenation of TDP-D-Quinovose

DesII, a radical SAM enzyme from Streptomyces venezuelae, catalyzes the deamination of TDP-4-amino-4,6- dideoxy-D-glucose to TDP-3-keto-4,6-dideoxy-D-glucose in the desosamine biosynthetic pathway. DesII can also catalyze the dehydrogenation of TDP-D-quinovose to the corresponding 3-keto sugar. Simi...

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Hlavní autoři: Ruszczycky, Mark W., Choi, Sei-hyun, Mansoorabadi, Steven O., Liu, Hung-wen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099232/
https://ncbi.nlm.nih.gov/pubmed/21513273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201212f
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