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Discovery of a potential allosteric ligand binding site in CDK2
Cyclin-dependent kinases (CDKs) are key regulatory enzymes in cell cycle progression and transcription. Aberrant activity of CDKs has been implicated in a number of medical conditions, and numerous small molecule CDK inhibitors have been reported as potential drug leads. However, these inhibitors ex...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3098941/ https://ncbi.nlm.nih.gov/pubmed/21291269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100410m |
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