A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

Sphingolipids, lipids with a common sphingoid base (also termed long chain base) backbone, play essential cellular structural and signaling functions. Alterations of sphingolipid levels have been implicated in many diseases, including neurodegenerative disorders. However, it remains largely unclear...

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Detalhes bibliográficos
Main Authors: Zhao, Lihong, Spassieva, Stefka D., Jucius, Thomas J., Shultz, Leonard D., Shick, H. Elizabeth, Macklin, Wendy B., Hannun, Yusuf A., Obeid, Lina M., Ackerman, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098191/
https://ncbi.nlm.nih.gov/pubmed/21625621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002063
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