Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

Ceramide metabolism has come under recent scrutiny because of its role in cellular stress responses. CerS2 (ceramide synthase 2) is one of the six mammalian isoforms of ceramide synthase and is responsible for the synthesis of VLC (very-long-chain) ceramides, e.g. C(24), C(24:1). To study the role o...

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Udgivet i:Biochem J
Main Authors: Spassieva, Stefka D., Mullen, Thomas D., Townsend, Danyelle M., Obeid, Lina M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603647/
https://ncbi.nlm.nih.gov/pubmed/19728861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090699
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