A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

Sphingolipids, lipids with a common sphingoid base (also termed long chain base) backbone, play essential cellular structural and signaling functions. Alterations of sphingolipid levels have been implicated in many diseases, including neurodegenerative disorders. However, it remains largely unclear...

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Hlavní autoři: Zhao, Lihong, Spassieva, Stefka D., Jucius, Thomas J., Shultz, Leonard D., Shick, H. Elizabeth, Macklin, Wendy B., Hannun, Yusuf A., Obeid, Lina M., Ackerman, Susan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098191/
https://ncbi.nlm.nih.gov/pubmed/21625621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002063
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