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Improved Total Synthesis of the Potent HDAC Inhibitor FK228 (FR-901228)
[Image: see text] A scaleable synthesis of the potent histone deacetylase (HDAC) inhibitor FK228 is described. A reliable strategy for preparing the key β-hydroxy mercapto heptenoic acid partner was accomplished in nine steps and 13% overall yield. A Noyori asymmetric hydrogen-transfer reaction esta...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097137/ https://ncbi.nlm.nih.gov/pubmed/18205373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol702957z |
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