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Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole
[Image: see text] The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880701/ https://ncbi.nlm.nih.gov/pubmed/19193120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807772w |
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