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Comparative Pharmacokinetic Properties and Antitumor Activity of the Marine HDACi Largazole and Largazole Peptide Isostere

PURPOSE: Largazole is a potent class I selective HDACi natural product isolated from the marine cyanobacteria Symploca sp. The purpose of this study was to test synthetic analogs of Largazole to identify potential scaffold structural modifications that would improve the drug-like properties of this...

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Bibliografski detalji
Izdano u:Cancer Chemother Pharmacol
Glavni autori: Pilon, John L., Clausen, Dane J., Hansen, Ryan J., Lunghofer, Paul J., Charles, Brad, Rose, Barbara J., Thamm, Douglas H., Gustafson, Daniel L., Bradner, James E., Williams, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368451/
https://ncbi.nlm.nih.gov/pubmed/25616967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2675-1
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