Comparative Pharmacokinetic Properties and Antitumor Activity of the Marine HDACi Largazole and Largazole Peptide Isostere

PURPOSE: Largazole is a potent class I selective HDACi natural product isolated from the marine cyanobacteria Symploca sp. The purpose of this study was to test synthetic analogs of Largazole to identify potential scaffold structural modifications that would improve the drug-like properties of this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Chemother Pharmacol
Prif Awduron: Pilon, John L., Clausen, Dane J., Hansen, Ryan J., Lunghofer, Paul J., Charles, Brad, Rose, Barbara J., Thamm, Douglas H., Gustafson, Daniel L., Bradner, James E., Williams, Robert M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368451/
https://ncbi.nlm.nih.gov/pubmed/25616967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2675-1
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg