Romidepsin (Istodax®, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T-cell Lymphoma

Romidepsin (Istodax(®)), a selective inhibitor of histone deacetylases (HDACs), was approved for the treatment of cutaneous T-cell lymphoma in November 2009 by the U.S. FDA. This unique natural product was discovered from cultures of Chromobacterium violaceum, a Gram-negative bacterium isolated from...

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Main Authors: VanderMolen, Karen M., McCulloch, William, Pearce, Cedric J., Oberlies, Nicholas H.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163831/
https://ncbi.nlm.nih.gov/pubmed/21587264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2011.35
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