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Mutations that replace aromatic side chains promote aggregation of the Alzheimer’s Aβ peptide
The aggregation of polypeptides into amyloid fibrils is associated with a number of human diseases. Because these fibrils – or intermediates on the aggregation pathway – play important roles in the etiology of disease, considerable effort has been expended to understand which features of the amino a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097045/ https://ncbi.nlm.nih.gov/pubmed/21513285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200268w |
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