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Small Molecule Microarrays Enable the Discovery of Compounds that Bind the Alzheimer’s Aβ Peptide

The amyloid-β (Aβ) aggregation pathway is a key target in efforts to discover therapeutics that prevent or delay the onset of Alzheimer’s disease. Efforts at rational drug design, however, are hampered by uncertainties about the precise nature of the toxic aggregate. In contrast, high-throughput scr...

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Bibliografski detalji
Glavni autori: Chen, Jermont, Armstrong, Anne H., Koehler, Angela N., Hecht, Michael H.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063105/
https://ncbi.nlm.nih.gov/pubmed/21062056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107552s
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