Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis

The S6K1 and S6K2 kinases are considered important mTOR signaling effectors, yet their contribution to tumorigenesis remains unclear. Aberrant mTOR activation is a frequent event in cancer, that commonly results from heterozygous loss of PTEN. Here, we show for the first time a differential protein...

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Main Authors: Nardella, Caterina, Lunardi, Andrea, Fedele, Giuseppe, Clohessy, John G., Alimonti, Andrea, Kozma, Sara C., Thomas, George, Loda, Massimo, Pandolfi, Pier Paolo
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096749/
https://ncbi.nlm.nih.gov/pubmed/21444676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3962
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