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Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

Wee1 inactivates the Cdc2–cyclin B complex during interphase by phosphorylating Cdc2 on Tyr-15. The activity of Wee1 is highly regulated during the cell cycle. In frog egg extracts, it has been established previously that Xenopus Wee1 (Xwee1) is present in a hypophosphorylated, active form during in...

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Autores principales: Lee, Joon, Kumagai, Akiko, Dunphy, William G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC30963/
https://ncbi.nlm.nih.gov/pubmed/11251070
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