Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

The order and fidelity of cell cycle events in mammals is intimately linked to the integrity of the Chk1 kinase-Cdc25A phosphatase pathway. Chk1 phosphorylation targets Cdc25A for destruction and, as shown here, inhibits interactions between Cdc25A and its mitotic substrate cyclin B1-Cdk1. Phosphory...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Chen, Mei-Shya, Ryan, Christine E., Piwnica-Worms, Helen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14559997/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7488-7497.2003
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