Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

The order and fidelity of cell cycle events in mammals is intimately linked to the integrity of the Chk1 kinase-Cdc25A phosphatase pathway. Chk1 phosphorylation targets Cdc25A for destruction and, as shown here, inhibits interactions between Cdc25A and its mitotic substrate cyclin B1-Cdk1. Phosphory...

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Bibliographic Details
Main Authors: Chen, Mei-Shya, Ryan, Christine E., Piwnica-Worms, Helen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC207598/
https://ncbi.nlm.nih.gov/pubmed/14559997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7488-7497.2003
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