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Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

Proliferating eukaryotic cells possess checkpoint mechanisms that block cell division in the presence of unreplicated or damaged DNA. Using cell-free extracts from Xenopus eggs, we have investigated the mechanisms underlying the inability of a recombinant Cdc2/cyclin B complex to induce mitosis in t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kumagai, A, Dunphy, W G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC275829/
https://ncbi.nlm.nih.gov/pubmed/7787246
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