Design and synthesis of RNA miniduplexes via a synthetic linker approach. 2. Generation of covalently closed, double-stranded cyclic HIV-1 TAR RNA analogs with high Tat-binding affinity.

We recently developed an approach which allows rapid generation of short, double-stranded oligonucleotides whereby one end of the duplex was joined and stabilized by a synthetic linker of specific design (miniduplexes)(6). Model miniduplexes based on the HIV-1 TAR RNA hairpin were shown to be thermo...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	X Ma, M Y, McCallum, K, Climie, S C, Kuperman, R, Lin, W C, Sumner-Smith, M, Barnett, R W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1993
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309585/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8332456/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.11.2585
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