Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

The yeast two-hybrid system and far-Western protein blot analysis were used to demonstrate dimerization of human double-stranded RNA (dsRNA)-dependent protein kinase (PKR) in vivo and in vitro. A catalytically inactive mutant of PKR with a single amino acid substitution (K296R) was found to dimerize...

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Main Authors: Cosentino, G P, Venkatesan, S, Serluca, F C, Green, S R, Mathews, M B, Sonenberg, N
Formato: Artigo
Idioma:Inglês
Publicado: 1995
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC40818/
https://ncbi.nlm.nih.gov/pubmed/7568151
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