Design and synthesis of RNA miniduplexes via a synthetic linker approach. 2. Generation of covalently closed, double-stranded cyclic HIV-1 TAR RNA analogs with high Tat-binding affinity.

We recently developed an approach which allows rapid generation of short, double-stranded oligonucleotides whereby one end of the duplex was joined and stabilized by a synthetic linker of specific design (miniduplexes)(6). Model miniduplexes based on the HIV-1 TAR RNA hairpin were shown to be thermo...

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Main Authors: X Ma, M Y, McCallum, K, Climie, S C, Kuperman, R, Lin, W C, Sumner-Smith, M, Barnett, R W
Formato: Artigo
Idioma:Inglês
Publicado: 1993
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC309585/
https://ncbi.nlm.nih.gov/pubmed/8332456
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