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Skp2 directs Myc-mediated suppression of p27(Kip1) yet has modest effects on Myc-driven lymphomagenesis
The universal cyclin-Cdk inhibitor p27(Kip1) functions as a tumor suppressor and reduced levels of p27(Kip1) connote poor prognosis in several human malignancies. p27(Kip1) levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the E3 ubi...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3095030/ https://ncbi.nlm.nih.gov/pubmed/20197382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0232 |
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