Reduced Sweetness of a Monellin (MNEI) Mutant Results from Increased Protein Flexibility and Disruption of a Distant Poly-(L-Proline) II Helix

Monellin is a highly potent sweet-tasting protein but relatively little is known about how it interacts with the sweet taste receptor. We determined X-ray crystal structures of 3 single-chain monellin (MNEI) proteins with alterations at 2 core residues (G16A, V37A, and G16A/V37A) that induce 2- to 1...

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Detalhes bibliográficos
Main Authors: Templeton, Catherine M., Ostovar pour, Saeideh, Hobbs, Jeanette R., Blanch, Ewan W., Munger, Steven D., Conn, Graeme L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094690/
https://ncbi.nlm.nih.gov/pubmed/21343241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/chemse/bjr007
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