MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

Although it is well established that tumors initiate an angiogenic switch, the molecular basis of this process remains incompletely understood. Here we show that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducing neovascularization. We iden...

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Autori principali: Anand, Sudarshan, Majeti, Bharat K, Acevedo, Lisette M, Murphy, Eric A, Mukthavaram, Rajesh, Scheppke, Lea, Huang, Miller, Shields, David J, Lindquist, Jeffrey N, Lapinski, Philip E, King, Philip D, Weis, Sara M, Cheresh, David A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094020/
https://ncbi.nlm.nih.gov/pubmed/20676106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2186
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