The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

The HECT-type ubiquitin ligase (E3) Smad ubiquitination regulatory factor 1 (Smurf1) targets various substrates, including Smad1/5, RhoA, Prickle 1, MEKK2, and JunB for degradation and thereby regulates adult bone formation and embryonic development. Here, we identify the endoplasmic reticulum (ER)-...

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Main Authors: Guo, Xing, Shen, Shan, Song, Shanshan, He, Shan, Cui, Yu, Xing, Guichun, Wang, Jian, Yin, Yuxin, Fan, Libin, He, Fuchu, Zhang, Lingqiang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093877/
https://ncbi.nlm.nih.gov/pubmed/21454619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225615
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