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A Bifacial Nucleoside as a Surrogate for both T and A in Duplex DNA
A new functional bifacial nucleoside derived from 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and incorporated into DNA oligonucleotides. The nucleobase, having self-complementary H-bonding faces, mimics both T and A, and engages in the correspond...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093761/ https://ncbi.nlm.nih.gov/pubmed/21495708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201397e |
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