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Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates

A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe–Ziegler cyclization. In addition to an adenosine and a guanosine mimic, analogues of the noncanonical xanthosine, isoguanosine, and...

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Foilsithe in:Chem Sci
Main Authors: Rovira, Alexander R., Fin, Andrea, Tor, Yitzhak
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380116/
https://ncbi.nlm.nih.gov/pubmed/28451365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05354h
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