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Enzymatic Interconversion of Isomorphic Fluorescent Nucleosides: Adenosine Deaminase Transforms (th)A to (th)I, Two Distinct Fluorophores
Adenosine deaminase, a major enzyme involved in purine metabolism, converts an isomorphic fluorescent analogue of adenosine ((th)A) to an isomorphic inosine analogue ((th)I), which possesses distinct spectral features, allowing one to monitor the enzyme-catalyzed reaction and its inhibition in real...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947497/ https://ncbi.nlm.nih.gov/pubmed/24288262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307064 |
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