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Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates

Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.

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Bibliografiske detaljer
Udgivet i:Chem Commun (Camb)
Main Authors: Shin, Dongwon, Lönn, Peter, Dowdy, Steven F., Tor, Yitzhak
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298453/
https://ncbi.nlm.nih.gov/pubmed/25500944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc08809c
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