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Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates
Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.
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| Pubblicato in: | Chem Commun (Camb) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298453/ https://ncbi.nlm.nih.gov/pubmed/25500944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc08809c |
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